Synthesis, Inhaltsverzeichnis Synthesis DOI: 10.1055/a-2744-6756 Paper Published as part of the Special Issue in Honor of Dr. Dani Schultz, the 2025 Women in Chemistry Award Winner Synthesis of Modified Fusicoccane Diterpenoids via Diverging MHAT Reactivity Autor*innen Institutsangaben Dylan W. Snelson 1 Department of Chemistry, Scripps Research, La Jolla, United States (Ringgold ID: RIN4356) Sebastian A. Fernandez 1 Department of Chemistry, Scripps Research, La Jolla, United States (Ringgold ID: RIN4356) Ryan A. Shenvi 1 Department of Chemistry, Scripps Research, La Jolla, United States (Ringgold ID: RIN4356) Artikel empfehlen Abstract Artikel einzeln kaufen(opens in new window) Alle Artikel dieser Rubrik(opens in new window) Dedication Dedicated to Dr. Dani Schultz for her outstanding leadership, scholarship, and science communication. Abstract Cotylenin and fusicoccin diterpene glycosides modulate the stability of 14-3-3 protein–client interactions. Here, we report the divergent syntheses of representative aglycons, brassicicene (BR-I), and talarmalnoid B (Tal-B) by modification of Studer’s Mukaiyama hydration variant. Keywords KeywordsMHAT - 14-3-3 - Fusicoccanes - Total synthesis - Natural products Volltext Referenzen References 1 Ohkanda J. Chem Lett 2021; 50 (01) 57-67 2 Hermeking H. Nat Rev Cancer 2003; 3 (12) 931-943 3 Boer BD. Trends Plant Sci 1997; 2 (02) 60-66 4 Molzan M, Kasper S, Röglin L. et al. ACS Chem Biol 2013; 8 (09) 1869-1875 5 Doveston RG, Kuusk A, Andrei SA. et al. FEBS Lett 2017; 591 (16) 2449-2457 6 Yamada K, Honma Y, Asahi K, Sassa T, Hino K, Tomoyasu S. Br J Haematol 2001; 114 (04) 814-821 7 Li F, Sun W, Guan J. et al. Org Biomol Chem 2018; 8 Yang C, Chen K, Liu Y. et al. Fitoterapia 2024; 179: 106262 9 De Boer AH, Leeuwen IJDV. Trends Plant Sci 2012; 17 (06) 360-368 10 Uwamori M, Osada R, Sugiyama R, Nagatani K, Nakada M. J Am Chem Soc 2020; 142 (12) 5556-5561 11 Jiang Y, Renata H. Nat Chem 2024; 16 (09) 1531-1538 12 Snelson DW, Ting SI, Shenvi RA. J Am Chem Soc 2025; 147 (01) 1327-1333 13 Ting SI, Snelson DW, Huffman TR, Kuroo A, Sato R, Shenvi RA. J Am Chem Soc 2023; 145 (37) 20634-20645 14 Sims NJ, Bonnet WC, Lawson DM, Wood JL. J Am Chem Soc 2023; 145 (01) 37-40 15 Chen B, Yang Y, Zhang X. et al. Org Lett 2023; 25 (48) 8570-8574 16 Chen B, Wu Q, Xu D. et al. Angew Chem 2022; 134 (19) e202117476 17 Chen B, Long K, Wang L, Chen Y. CCS Chem 2025; 1-10 18 Guan Z, Yuan Y, Zhang X-J. et al. Chemistry 2024; 11 19 Pedras MSC, Chumala PB, Jin W, Islam MS, Hauck DW. Phytochemistry 2009; 70 (03) 394-402 20 Cinelli MA, Do HT, Miley GP, Silverman RB. Med Res Rev 2020; 40 (01) 158-189 21 Bhunia A, Bergander K, Daniliuc CG, Studer A. Angew Chem Int Ed 2021; 60 (15) 8313-8320 22 Shevick SL, Wilson CV, Kotesova S, Kim D, Holland PL, Shenvi RA. Chem Sci 2020; 11 (46) 12401-12422 23 Kim D, Rahaman SMW, Mercado BQ, Poli R, Holland PL. J Am Chem Soc 2019; 141 (18) 7473-7485 24 Crossley SWM, Obradors C, Martinez RM, Shenvi RA. Chem Rev 2016; 116 (15) 8912-9000 25 Kong L, Gan X, Van Der Puyl Lovett VA, Shenvi RA. J Am Chem Soc 2024; 146 (04) 2351-2357 Zusatzmaterial Zusatzmaterial Ergänzendes Material (PDF) (opens in new window)
